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Ǵм Yeungnam Univ J Med 2018;35(1):40-44

ORIGINAL ARTICLE

Effect of preoperative pregabalin on postoperative pain after gastrectomy

Chan Yoon Park1, Sol Hee Park1, Dong Gun Lim1, Eun Kyung Choi2
1Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Kyungpook National University
Hospital; 2Department of Anesthesiology and Pain Medicine, Yeungnam University College of Medicine, Daegu, Korea
Corresponding Author: Eun Kyung Choi, Department of Anesthesiology and Pain Medicine, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu 42415, Korea
Tel: +82-53-620-3361, Fax: +82-53-626-5275
E-mail: zzini0527@naver.com

Received: February 2, 2018, Revised: February 19, 2018 Accepted: March 2, 2018

Abstract

Background: Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of pregabalin in resolving post-gastrectomy pain. Methods: Forty-four patients were randomized into two groups: a pregabalin group that received oral pregabalin (150 mg) 2 h before anesthetic induction, and a control group that received placebo tablets at the same time. Data on postoperative pain intensity (visual analog scale [VAS], at 30 min, 2 h, 4 h, and 24 h), consumption of fentanyl in patient-controlled analgesia (PCA), and the proportion of patients requiring rescue analgesics at different time intervals (0-2 h, 2-4 h, and 4-24 h) were collected during the 24 h postoperative period. Results: The VAS scores did not show significant differences at any time point and consumption of fentanyl in PCA and the proportion of patients requiring rescue analgesics did not differ between the two groups. The groups did not differ in the occurrence of dizziness, sedation, and dry mouth. Conclusion: A preoperative 150 mg dose of pregabalin exerts no effect on acute pain after gastrectomy.

Key Words: Keywords: Pregabalin; Postoperative pain; Gastrectomy

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