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¿µ³²ÀÇ´ëÇмúÁö Vol.24_No.2 Suppl. P.S399-406, Dec. 2007
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Original Article
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Àç¹ß À§¾ÏȯÀÚ¿¡¼ 2Â÷ ±¸Á¦¿ä¹ýÁ¦·Î¼ÀÇ DocetaxelÀ» Æ÷ÇÔÇÑ Ç×¾ÏÈÇпä¹ýÀÇ Ä¡·á ¼ºÀû ¹× ºÎÀÛ¿ë |
Efficacy and Side Effect of Docetaxel Based Chemotherapy as Second-Line Treatment in Recurrent Gastric Cancer
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Tel: (053) 620-3586, Fax: (053) 624-1213
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E-mail: sksong@med.yu.ac.kr
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December 30, 2007
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Abstract
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Purpose£ºTo investigate the efficacy and safety of docetaxel based chemotherapy as a second- line treatment in patients with metastatic or recurrent gastric cancer.
Materials and Methods£ºBetween January 2001 and March 2007, 28 patients with recurrent or metastatic gastric cancer were enrolled. The administered doses of decetaxel was 75 mg/m2 on day 1 and 5, cisplatin 60 mg/m2 on day 3, 5-FU 600 mg/m2 over 24 hrs on day 1 to day 5, every 4 weeks. The response was assessed every 2 cycles. The toxicities were evaluated for every course of chemotherapy according to National Cancer Institute-common toxicity criteria (NCI-CTC).
Results£ºFor response rates, 3 (10.7%) partial response, 13 (46.4%) stable disease, and 12 (42.9%) progressive disease, respectively. The overall disease control rate was 57.1%. The median time to progression was 3.0 months (2-8 months). Median overall survival was 8 months (5-11 months). NCI-CTC grade 3 leukocytopenia occurred in 1 cases, grade 3 anemia in 1case and grade 3 nausea/vomiting in 2 cases.
Conclusion£ºDocetaxel based chemotherapy has a tolerable efficacy with acceptable toxicities in patients with recurrent gastric cancer as a second-line treatment.
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Key Words: Docetaxel, Chemotherapy, Gastric cancer
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