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영남의대학술지 Vol.24_No.2 Suppl. P.S399-406, Dec. 2007

Original Article

재발 위암환자에서 2차 구제요법제로서의 Docetaxel을 포함한 항암화학요법의 치료 성적 및 부작용

Efficacy and Side Effect of Docetaxel Based Chemotherapy as Second-Line Treatment in Recurrent Gastric Cancer

김세원, 김상운, 송선교
영남대학교 의과대학 외과학교실
책임저자:송선교, 대구광역시 남구 대명 5동 317-1, 영남대학교 의과대학 외과학교실
Tel: (053) 620-3586, Fax: (053) 624-1213
E-mail: sksong@med.yu.ac.kr

December 30, 2007


Purpose:To investigate the efficacy and safety of docetaxel based chemotherapy as a second- line treatment in patients with metastatic or recurrent gastric cancer.
Materials and Methods:Between January 2001 and March 2007, 28 patients with recurrent or metastatic gastric cancer were enrolled. The administered doses of decetaxel was 75 mg/m2 on day 1 and 5, cisplatin 60 mg/m2 on day 3, 5-FU 600 mg/m2 over 24 hrs on day 1 to day 5, every 4 weeks. The response was assessed every 2 cycles. The toxicities were evaluated for every course of chemotherapy according to National Cancer Institute-common toxicity criteria (NCI-CTC).
Results:For response rates, 3 (10.7%) partial response, 13 (46.4%) stable disease, and 12 (42.9%) progressive disease, respectively. The overall disease control rate was 57.1%. The median time to progression was 3.0 months (2-8 months). Median overall survival was 8 months (5-11 months). NCI-CTC grade 3 leukocytopenia occurred in 1 cases, grade 3 anemia in 1case and grade 3 nausea/vomiting in 2 cases.
Conclusion:Docetaxel based chemotherapy has a tolerable efficacy with acceptable toxicities in patients with recurrent gastric cancer as a second-line treatment.

Key Words: Docetaxel, Chemotherapy, Gastric cancer


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