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영남의대학술지 Vol.24_No.2 Suppl. P.S384-390, Dec. 2007

Original Article

궤양성 직장염은 치료에 관계없이 전대장염으로 진행하는가?

Does Ulcerative Proctitis Progress to Extensive Colitis Depending on Treatment?

박윤선, 장병익, 김태년

영남대학교 의과대학 내과학교실

책임저자：장병익, 대구광역시 남구 대명5동 317-1, 영남대학교 의과대학 내과학교실

H.P: 010-7470-7172, Fax: (053) 624-8386

E-mail: jbi@med.yu.ac.kr

December 30, 2007

Abstract

Background：The incidence of Ulcerative colitis (UC) in Korea are low compared with those of Western countries, but have been increasing rapidly during the past decades. Clinical characteristics of UC in Asian population are not well recognized. Therefore we investigated the clinical course of UC in Korea.
Material and Methods：We retrospectively analyzed 211 UC patients first diagnosed and long term follow up colonoscopic examined at Yeungnam University Medical Center between 1989 and 2006. We reviewed extension of lesion by follow up endoscopic finding and symptom depend on treatment.
Results：The male to female ratio was 1:1.1 and the median age at diagnosis was 46.0 years (range, 17-83 years). At diagnosis, proctitis was noted in 70 patients (33.2%), proctosigmoiditis in 40 (19%), left-sided colitis in 22 (10.4%), extensive colitis in 79 (37.4%). Further extension in the colon was most frequently observed in patients with proctitis (22.8%). In the patients initially diagnosed with proctitis, 28.6% of the patients were not taking any kind of medication for UC and 54 patients (77%, treatment group 34 patients, untreatment group 20) had not progressed during the observation period (56 months, range 2-193 months). The maximal extent of the disease was not affected by treatment (P = 0.99).
Conclusion：The initial extent of the disease in Korean UC patients was similar to that found in other Western studies. In the present study, most of limited UC(proctitis, proctosigmoiditis, 77-82%) did not progress to extensive colitis regardless of treatments, but large scale multi- center analysis was needed.

Key Words: Ulcerative colitis, disease progression

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