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영남의대학술지 Vol.24_No.2 Suppl. P.S270-276, Dec. 2007
Review
골면역학
Osteoimmunology
정대원
영남대학교 의과대학 미생물학교실
책임저자：정대원, 대구광역시 남구 대명 5동 317-1, 영남대학교 의과대학 미생물학교실
Tel: (053) 620-4365, Fax: (053) 653-6628
E-mail: dwjeong@ynu.ac.kr
December 30, 2007
Abstract
Bone is the only solid organ and serves as a mechanical support and a reservoir of minerals. Bone homeostasis is achieved by the balance between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts, which are derived from mesenchymal stem cells, secrete bone matrix proteins and promote mineralization. Otherwise, osteoclasts are derived from hematopoietic stem cells (HSC) that are capable of differentiating into all immune cells and resorb bone matrix by acid decalcification and proteolytic degradation. Osteobalsts and osteoclasts are an important role in the regulation of HSC niche and development, showing that bone remodeling was linked to hematopoietic regulation. Long-lived memory T and B cells and bone cells coexist in the bone marrow reservoir as well as activated T cells that mediate adaptive immune system and osteoclasts that regulate bone turnover share a common molecules that are essential for their development and differentiation. In addition, activated T cell-expressed RANKL directly stimulates osteoclastogenesis. Accumulating evidence indicates that there is the interplay between the immune-related cells and bone remodeling-related cells. This review will discuss the osteoimmunology, an interdisciplinary approach to understanding the cross-talk between bone and the immune cells. 감사의 글 본 종설은 한국과학재단으로부터 영남대학교 노인성혈관질환연구센터에 제공된 기금(R13- 2005-005-01004-0)으로 수행되었다.
Key Words: Bone, Osteoblast, Osteoclast, Immune cells, Osteoimmunology
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