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Ǵм Vol.24_No.2 Suppl. P.S142-151, Dec. 2007

Review

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latelet Activating Factor-Acetylhydrolase

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åڣ, 뱸 5 317-1, б ǰ ̻б
Tel: (053) 620-4362, Fax: (053) 653-6628
E-mail: doxr7p@med.yu.ac.kr

December 30, 2007

Abstract

Platelet activating factor (PAF) is a phospholipid with a strong inflammatory mediator. PAF is synthesized in a variety of cells in response to inflammatory stimuli. PAF is degraded by intracellular and extracellular PAF-acetylhydrolases (PAF-AHs) thus providing proper level of PAF. Plasma PAF-AH deficiency is associated with several diseases such as asthma, systemic lupus erythematosus, juvenile rheumatoid arthritis, acute myocardial infarction, diabetes, and membranous nephropathy. Cloning of plasma PAF-AH gene enabled the use of recombinant PAF-AH as a therapeutic tool for these PAF-mediated diseases.

Key Words: KeyWords:Platelet activating factor, Platelet activating factor-acetylhydrolase, disease, recombinant, treatment

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